Multi-site meta-analysis of image-wide genome-wide associations of morphometry
نویسندگان
چکیده
150/150). Large-scale distributed analyses of over 30,000 MRI scans recently detected common genetic variants associated with the volumes of subcortical brain structures. Scaling up these efforts, still greater computational challenges arise in screening the genome for statistical associations at each voxel in the brain, localizing effects using “image-wide genome-wide” testing (voxelwise GWAS, vGWAS). Here we benefit from distributed computations at multiple sites to meta-analyze genome-wide image-wide data, allowing private genomic data to stay at the site where it was collected. Site-specific tensorbased morphometry (TBM) is performed with a custom template for each site, using a multi channel registration. A single vGWAS testing 10 variants against 2 million voxels can yield hundreds of TB of summary statistics, which would need to be transferred and pooled for meta-analysis. We propose a 2-step method, which reduces data transfer for each site to a subset of SNPs and voxels guaranteed to contain all significant hits.
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